http://www.sciencedaily.com/releases/2011/06/110606142342.htm
In the first study on yo-yo dieting of its kind, List and colleagues followed 30 mice on one of three dietary regimens over the course of a little over two years, the typical lifespan of this particular strain of laboratory mouse. The animals on the high-fat diet ate more, weighed more and had higher levels of body fat and fasting blood glucose. They also become glucose intolerant, or pre-diabetic, said List, whose research is supported by the National Institutes of Health, AMVETS and Ohio University.
The health profile of the mice on the yo-yo diet declined during their high-fat food phases, but their weight and blood glucose levels returned to normal levels during their low-fat diet stages. Lifespan -- the "gold standard" for lifelong health status -- was 2.04 years for the yo-yo dieting mice, compared to 1.5 years for the obese mice. The control group lived, on average, for 2.09 years.
About 34 percent of American adults are considered to be obese; an additional 34 percent are classified as overweight, according to the Centers for Disease Control and Prevention. Although millions of Americans diet each year, research has shown that few people maintain long-term weight loss.
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